Terranova NextGen

The next generation of nutraceutical product development.

The Challenge

Many isolated plant actives and nutraceutical compounds are known to have exceedingly low bioavailability, meaning that you may not experience the full value of taking them. For example, standard forms of resveratrol and curcumin have been reported to have bioavailability as low as 1%. Even bioavailable ingredients in supplements can be influenced by the body’s biological environment in a manner which may adversely affect their utilisation and functions.

The Solution

The unique and dynamic partnership of BioSNEDS™ and MAGNIFOOD™.

BioSNEDS™

A revolution in bioavailability.

Created by the visionary scientific forces of Verdant Nature, BioSNEDS™ is a self-emulsifying nutrient delivery system that significantly enhances bioavailability of various plant compounds and nutritional actives.

Bioavailability

the proportion of active ingredients absorbed and delivered to targeted cells, has long been a significant challenge in supplementation.

MAGNIFOOD™

A revolution in nutritional synergy.

Terranova’s intensely synergistic innovation, Magnifood, is a tailored complex of botanicals and phytonutrient-rich foods designed to support the absorption, bioavailability, utilization, activity, stability, function and effect of the nutritional ingredients in each product.

Synergy

Not just an advantage, synergy is the key to unlocking true nutritional effectiveness, enhancing even the most advanced delivery technologies.

25
times more bioavailable*
40.2
times more bioavailable*
15.3
times more bioavailable*
43.3
times more bioavailable*
44.4
times more bioavailable*

How BioSNEDS™ Works

1
High-quality plant compounds / bio actives such as resveratrol or curcumin, are fermented with probiotic and nutritional yeasts.
2
During fermentation, the bio actives are encapsulated within glucan particles, protecting them from degradation and ensuring stability.
3
The glucan-encapsulated bio actives are further encapsulated in a lipid-based matrix and upon contact with digestive juices, the lipid system forms emulsions, enhancing dispersibility and facilitating absorption.
4
The ‘double bubble’ BioSNEDS bio active uses the lymphatic system as a pathway, bypasses the liver’s first-pass metabolism, ensuring higher bioavailability and cell-targeted delivery.

Overcoming the liver first-pass effect

Conventional
When nutraceutical products are taken orally, they are absorbed in the stomach and intestines before being transported to the liver via the bloodstream. This process, known as the liver first-pass effect, involves the liver metabolizing and breaking down a portion of the active ingredients before they can enter systemic circulation. As a result, bioavailability can be significantly reduced.
BioSNEDS™
When nutraceutical products are taken orally, they are absorbed in the stomach and intestines before being transported to the liver via the bloodstream. This process, known as the liver first-pass effect, involves the liver metabolizing and breaking down a portion of the active ingredients before they can enter systemic circulation. As a result, bioavailability can be significantly reduced.
Think of BioSNEDSTM like a ‘smart delivery system’ for bio actives, instead of getting lost, they are carefully delivered to the cells via the lymphatic system.
The mechanism of a BioSNEDS™ bio active being taken up by the lymphatic system involves chylomicrons. Chylomicrons are lipoproteins that transport dietary lipids and nutrients/ nutraceutical ingredients from the intestines to tissues, where lipoprotein lipase (LPL) releases their contents for uptake or redistribution.

Scientific validation by PK and PAMPA

Conventional
Pharmacokinetic (PK) studies highlight the use of BioSNEDS™ in achieving superior bioavailability compared to traditional methods. PK studies are important in understanding how BioSNEDS™ Technology optimizes nutrient delivery by ensuring higher availability in the body’s circulatory system.
Parallel Artificial Membrane Permeability Assays (PAMPA)
PAMPA is a measure of efficient absorption through the intestinal epithelium, showing BioSNEDS™ ability to effectively overcome intestinal absorption barriers and ensuring that active ingredients reach their intended targets.
PK STUDIES
CurcuSOLTM VS CURCUMIN
BioSNEDS™ CurcuSolTM achieved a 40.2-fold enhancement in bioavailability compared to conventional curcumin.
CurcuSOLTM
Curcumin
CoQXorbTM VS COQ10
BioSNEDS™ CoQXorb™ achieved a 25-fold enhancement in bioavailability compared to conventional coQ10.
CoQXorbTM
CoQ10
QuerceSOLTM VS QUERCETIN
BioSNEDS™ QuerceSOL™ achieved a 15.3-fold enhancement in bioavailability compared to conventional quercetin.
BioQuercetin
Quercetin
NADProTM VS NIACINAMIDE/QUERCETIN
BioSNEDS™ NADPro™ achieved a 44.4-fold enhancement in quercetin bioavailability compared to conventional niacinamide/ quercetin.
NADProTM
Niacinamide/Quercetin
ResveraSOLTM VS RESVERATROL
BioSNEDS™ ResveraSol™ achieved a 43.3-fold enhancement in bioavailability compared to conventional resveratrol.
ResveraSOLTM
Resveratrol

BioSNEDS™ vs Liposomes

Self-Emulsifying Delivery Systems are a clean, pure and effective delivery system of choice to overcome the limitations of Liposomes.
The NextGen range introduces a revolution in supplement technology, offering formulations that rise above the abilities of traditional delivery systems, including liposomal technology.

Why choose Terranova NextGen?

  • Maximized Bioavailability
  • Targeted Delivery
  • Synergistic Formulations
  • Cutting-Edge Innovation
  • Scientific Validation
  • No Need For High Dose
  • Value For Money
  • Clean Technology
  • Suitable For Vegans
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